BIOZYME, INC. BioZyme, Inc. specializes in offering fluorescent (FRET) substrates for the Matrix Metalloproteinase (MMP) and A Disintegrin and Metalloproteinase (ADAM) Family members which are both sensitive and selective. We have numerous substrates in stock at very competitive prices.
See our online catalog or our individual Product Sheets located on this website.
Many of Biozyme, Inc. ADAM and MMP fluorescent substrates have been used successfully to screen different types of biological samples. Our ADAM and MMP substrates have been used with a technique called proteolytic matrix analysis (PrAMA) to decipher the contributions of different metalloproteinase activities in a biological sample even though the substrates are not completely selective. With this technique, the MMP and ADAM substrates have helped quantify MMP9, MMP2, MT1-MMP, ADAM9, ADAM17, ADAM10, ADAM12, and ADAM8 activities to name a few. See our publication list for details.
The ADAM substrates and MMP substrates are well characterized and have also been used with cell-based assays and purified enzyme preparations. The most specific ADAM fluorescent substrates are for ADAM8, ADAM10 and ADAM17. However, we also provide highly sensitive fluorogenic substrates that are useful also for individual assays or high throughput screening for ADAM17, ADAM9, ADAM10, ADAM8 and ADAM12, MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP13 and MMP14 (MT1-MMP).
Biozyme, Inc. also offers NEW PRODUCTS:
An ADAM substrate which is the MCA/DNP version of PEPDAB005, Catalog Number: PEPMCA002, with a new promotional price of 1mg, 80 USD.
An ADAM10 selective substrate, TENtide, Catalog Number: PEPMCA001
A new ADAM17 sensitive and selective substrate based on TACEtide, Catalog Number: PEPDAB064
A selective ADAM10 substrate, useful for cell based assays, Catalog Number: PEPDAB063
A new sensitive substrate for MMP9, MMP3, MMP1 and MMP14 or MT1-MMP with a new promotional price of 1mg, 80 USD, Catalog Number: PEPDAB061